In addition to breast cancer, the team is interested in the non-invasive diagnosis of tuberculosis (TB) in patient urine.With the emergence of drug resistant variants, the World Health Organization has redefined TB as a global health crisis. Yet, early diagnosis of the disease is a challenge. Preliminary studies, performed in collaboration with the National Institutes of Health, have indicated that at least three different bacterial biomarkers specific to Mycobacterium tuberculosis are secreted in the urine of patients with the multi-drug resistant TB (MDR-TB).We are currently optimizing immunoassays for these markers for application to the waveguide platform. We hope to explore the presence of biomarkers in patient urine as well as evaluate any differential expression of these biomolecules in MDR versus. regular TB. The project will definitely contribute to our understanding of TB biomarkers and may serve as a diagnostic tool for the disease.